MRI-guided focused ultrasound (MRgFUS) system for thermal ablation of prostate cancer: pre-clinical evaluation in canines

Nathan McDannold; Hadas Ziso; Benny Assif; Arik Hananel; Natalia Vykhodtseva; Peri Gretton; Magdalini Pilatou; Steven Haker; Clare Tempany

doi:10.1117/12.811178

23 February 2009 MRI-guided focused ultrasound (MRgFUS) system for thermal ablation of prostate cancer: pre-clinical evaluation in canines

Nathan McDannold, Hadas Ziso, Benny Assif, Arik Hananel, Natalia Vykhodtseva, Peri Gretton, Magdalini Pilatou, Steven Haker, Clare Tempany

Author Affiliations +

Proceedings Volume 7181, Energy-based Treatment of Tissue and Assessment V; 71810H (2009) https://doi.org/10.1117/12.811178
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

A transrectal MRgFUS system was tested in a canine prostate model. Focal volumes in each half of the prostate were targeted, with high energy in one half of the gland for ablation and in the other with lower-energy sonications to test our ability to localize the focal spot before causing thermal tissue damage. All sonications (n=155) were readily observed with proton resonance frequency (PRF) MR temperature imaging, contrast enhanced MRI and histology. The prostate gland moved during the experiments, demonstrating the need for motion tracking. The resultant focal temperature changes during the experiments were 24.2 ± 8.2°C.

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Nathan McDannold, Hadas Ziso, Benny Assif, Arik Hananel, Natalia Vykhodtseva, Peri Gretton, Magdalini Pilatou, Steven Haker, and Clare Tempany "MRI-guided focused ultrasound (MRgFUS) system for thermal ablation of prostate cancer: pre-clinical evaluation in canines", Proc. SPIE 7181, Energy-based Treatment of Tissue and Assessment V, 71810H (23 February 2009); https://doi.org/10.1117/12.811178

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