12 February 2009 A novel microthermal probe for the measurement of perfusion
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Abstract
Using micro-fabrication techniques a micro thermal probe has been developed in our laboratory to measure the thermal conductivity of biological tissues. This paper presents our latest experimental results which demonstrate the usefulness of the micro thermal probe in mapping the complicated perfusion field inside biological tissues. A perfused pig liver model has been constructed to simulate in vivo conditions. The portal vein and hepatic artery of a porcine liver were intubated and connected to a perfusion circuit. Saline water was perfused through the liver driven by a peristaltic pump. By varying the pumping rate of the perfused model, we measured the effective thermal conductivity at different perfusion rates in different locations. The results show that the effective thermal conductivity varies with the square root of the perfusion rate. Also, by rotating the micro probes, we observed a strong directional dependence of the effective thermal conductivity, revealing that perfusion is not a scalar but a vector field.
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Ming Yi, Aditya Kausik, Ronald J. Podhajsky, Roop L. Mahajan, "A novel microthermal probe for the measurement of perfusion", Proc. SPIE 7181, Energy-based Treatment of Tissue and Assessment V, 71810S (12 February 2009); doi: 10.1117/12.808538; https://doi.org/10.1117/12.808538
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