12 February 2009 In vivo optical analysis of pancreatic cancer tissue in living model mice using fluorescence and Raman spectroscopic techniques
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Abstract
Living pancreatic cancer tissues grown subcutaneously in nude mice are studied by in vivo Raman spectroscopy and autofluorescence imaging. Comparing the same point spectra of alive pancreatic cancer tissue to that of the dead tissue, it is found that they are different each other. The results suggest that the spectral changes reflect the protein conformational changes in the tumor tissue with death of the host animal. From the result of autofluorescence study, in vivo autofluorescence imaging has potential as a method to assign the histological elements of the pancreatic cancer tissue without any staining. These results strongly suggest that combination of these techniques is very important to study biological tissue.
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Toshiaki Suzuki, Toshiaki Suzuki, Yusuke Hattori, Yusuke Hattori, Takashi Katagiri, Takashi Katagiri, Hiroki Mitsuoka, Hiroki Mitsuoka, Ken-ichi Sato, Ken-ichi Sato, Toru Asakura, Toru Asakura, Toru Shimosegawa, Toru Shimosegawa, Hidetoshi Sato, Hidetoshi Sato, } "In vivo optical analysis of pancreatic cancer tissue in living model mice using fluorescence and Raman spectroscopic techniques", Proc. SPIE 7182, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VII, 718202 (12 February 2009); doi: 10.1117/12.808832; https://doi.org/10.1117/12.808832
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