Effect of time gating and polarization discrimination of propagating light in turbid media during angular domain imaging (ADI)

Fartash Vasefi; Eldon Ng; Bozena Kaminska; Glenn H. Chapman; Jeffrey J. L. Carson

doi:10.1117/12.809439

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23 February 2009 Effect of time gating and polarization discrimination of propagating light in turbid media during angular domain imaging (ADI)

Fartash Vasefi, Eldon Ng, Bozena Kaminska, Glenn H. Chapman, Jeffrey J. L. Carson

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Proceedings Volume 7182, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VII; 718217 (2009) https://doi.org/10.1117/12.809439
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Angular Domain Imaging (ADI) employs an angular filter array to accept photons within a small acceptance angle along the axis of an aligned laser light source and preferentially reject scattered light. Simulations show that the accepted photons travel the shortest paths between source and detector and are therefore the earliest to arrive. We fabricated angular filter arrays using silicon bulk micromachining and found that an array of 60 μm square shape microtunnels 1 cm in length accepted photons within 0.48 degree of axis of the micro-tunnels. This small acceptance angle rejected most of the scattered light and sub-millimeter resolution targets could be resolved in a few centimeters of turbid medium with at least six times reduced mean free path. ADI through media with higher scattering coefficients was not achievable due to unwanted acceptance of late arriving scattered photons. To reject the late arriving photons, we added time-domain filtration and linear polarization to ADI. The implementation of a time-gated camera, a 780 nm femtosecond pulsed laser, and linear polarization to our ADI system resulted in improved image contrast. The use of ADI with time-gating (gate width 250 ps) and linear polarization enabled visualization of sub-millimeter absorbing objects with approximately eight times higher image contrast compared to ADI in a scattering medium equivalent to six times reduced mean free path.

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Fartash Vasefi, Eldon Ng, Bozena Kaminska, Glenn H. Chapman, and Jeffrey J. L. Carson "Effect of time gating and polarization discrimination of propagating light in turbid media during angular domain imaging (ADI)", Proc. SPIE 7182, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VII, 718217 (23 February 2009); https://doi.org/10.1117/12.809439

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