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13 February 2009 Third and second harmonic generation imaging of human articular cartilage
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Cartilage matrix is damaged in diseased states such as osteoarthritis, while adult articular cartilage does not have the capacity to repair structural damage. A least invasive mean to diagnose these diseased states of human articular cartilage with a high spatial resolution is thus highly desired. In this paper, we present our harmonic generation microscopic studies on the human articular cartilage samples. Without any staining, third and second harmonic generation can provide strong contrast in chondrocytes and collagen matrix, respectively. Our study indicates the high capability of harmonic generation microscopy for future articular cartilage disease diagnosis.
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Ming-Rung Tsai, Chih-Hwa Chen, and Chi-Kuang Sun "Third and second harmonic generation imaging of human articular cartilage", Proc. SPIE 7183, Multiphoton Microscopy in the Biomedical Sciences IX, 71831V (13 February 2009);

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