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24 February 2009 Effect of spontaneous diffusion in micro/nanoporous chemically crosslinked poly (N-vinyl imidazole) gel on the conformational changes of acetylcholine
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Abstract
Interdependent structural properties such as molecular conformation, flexibility and charge redistribution control the intermolecular interactions of acetylcholine (ACh) with adjacent molecules. This paper reports the results of an investigation of the effect of the diffusion of ACh through a nano/microporous poly (N-vinylimidazole) (PVI) gel on its structural properties, namely on changes in its conformation. To investigate the conformational changes of ACh during spontaneous diffusion through the gel, the fluorescence lifetime of the label molecule - fluorescein - was monitored. To clarify the results, analogous experiments were conducted with nicotinic acid and dopamine. In contrast to the nicotinic acid and dopamine, ACh can play the role of a regulator in molecular transport.
© (2009) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Evgenia Vaganova, Ines F. Pierola, Haim Ovadia, Sergey E. Lyshevski, and Shlomo Yitzchaik "Effect of spontaneous diffusion in micro/nanoporous chemically crosslinked poly (N-vinyl imidazole) gel on the conformational changes of acetylcholine", Proc. SPIE 7185, Single Molecule Spectroscopy and Imaging II, 718516 (24 February 2009); https://doi.org/10.1117/12.809083
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