20 February 2009 Noninvasive NIR monitoring of interstitial ethanol concentration
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Abstract
A practical limitation encountered in alcohol research is the relatively small number of body compartments (e.g. blood, liver, tissue) that can be directly interrogated. In this work, an NIR spectroscopic device was investigated that provided a direct measurement of alcohol concentration in skin tissue (interstitial fluid). This work is intended to characterize the relationship of forearm interstitial fluid alcohol concentration relative to capillary blood using a first order kinetic model. Concurrent blood and tissue alcohol concentrations were collected on 101 test subjects while consuming alcohol. Estimates of the first order kinetic rate constant were calculated for each of the subjects. It is hoped that this characterization will lead to further improvements in optical based alcohol monitors for impairment detection.
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Trent D. Ridder, Trent D. Ridder, Benjamin J. Ver Steeg, Benjamin J. Ver Steeg, Stephen J. Vanslyke, Stephen J. Vanslyke, Jeff F. Way, Jeff F. Way, } "Noninvasive NIR monitoring of interstitial ethanol concentration", Proc. SPIE 7186, Optical Diagnostics and Sensing IX, 71860E (20 February 2009); doi: 10.1117/12.809944; https://doi.org/10.1117/12.809944
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