Influence of skin tissue properties on the radial reference point for glucose measurement

Yue Yang; Kexin Xu; Lijun Ding; Zhenzhi Shi; Wenliang Chen

doi:10.1117/12.808693

20 February 2009 Influence of skin tissue properties on the radial reference point for glucose measurement

Yue Yang, Kexin Xu, Lijun Ding, Zhenzhi Shi, Wenliang Chen

Proceedings Volume 7186, Optical Diagnostics and Sensing IX; 71860N (2009) https://doi.org/10.1117/12.808693
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

A reference position where the diffuse reflectance light intensity is insensitive to the variation of glucose concentration exists in the radial detection space for glucose measurement in the scattering medium such as skin. The signal measured in this position could be used as an inside reference to evaluate the influence on spectrum caused by other interferential factors. The relationship between the position of radial reference point and the skin tissue property is studied in this paper. Three-layer skin models with different optical parameters are designed to get sample sets at 1200~1700nm. In these sets, μ_a, μ_s and g of dermis varies respectively, so does the depth of epidermis or dermis. The distribution rule of dispersion of diffuse reflectance light intensity in the radial space is confirmed with the glucose concentration changes. And the distribution property of the radial reference position in every sample set is obtained through Monte Carlo simulation. The result shows that the distance of radial reference position from light source is insensitive to the variation of absorption coefficient or the depth of dermis, but an increased scattering coefficient will shorten the distance; an increased anisotropy coefficient or depth of epidermis will lengthen it. On the basis of that, the optical probes with different structures are designed according to the skin tissue properties. So they could be used for the measurement of corresponding patients, which enhances the practicability of floating reference method greatly.

Citation Download Citation

Yue Yang, Kexin Xu, Lijun Ding, Zhenzhi Shi, and Wenliang Chen "Influence of skin tissue properties on the radial reference point for glucose measurement", Proc. SPIE 7186, Optical Diagnostics and Sensing IX, 71860N (20 February 2009); https://doi.org/10.1117/12.808693

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