24 February 2009 Optimizing Fourier-domain angle resolved low coherence interferometry for clinical use
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Abstract
Methods for the optimization of a/LCI for clinical use are presented. First, the use of the T-matrix light scattering model to simulate scattering from spheroidal particles is presented as a more appropriate simulation of cell nuclei scattering than the previously used Mie theory. In addition, the use of a broadband light source with a bandwidth greater than 50nm similar to those utilized in OCT applications is demonstrated. Accurate sizing of scatterers in tissue phantoms containing stretched and unstretched polystyrene microspheres along with measurements of unstretched polystyrene microspheres in solution are presented, demonstrating advances in system performance and design. In addition, preliminary human in vivo esophageal tissue data are presented.
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Neil G. Terry, Neil G. Terry, Yizheng Zhu, Yizheng Zhu, Matthew Rinehart, Matthew Rinehart, Adam Wax, Adam Wax, } "Optimizing Fourier-domain angle resolved low coherence interferometry for clinical use", Proc. SPIE 7187, Biomedical Applications of Light Scattering III, 71870W (24 February 2009); doi: 10.1117/12.808021; https://doi.org/10.1117/12.808021
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