Silicates doped with luminescent ions: useful tools for optical imaging applications

Quentin le Masne de Chermont; Cyrille Richard; Johanne Seguin; Corinne Chanéac; Michel Bessodes; Daniel Scherman

doi:10.1117/12.819316

3 March 2009 Silicates doped with luminescent ions: useful tools for optical imaging applications

Quentin le Masne de Chermont, Cyrille Richard, Johanne Seguin, Corinne Chanéac, Michel Bessodes, Daniel Scherman

Proceedings Volume 7189, Colloidal Quantum Dots for Biomedical Applications IV; 71890B (2009) https://doi.org/10.1117/12.819316
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Fluorescence is increasingly used for in vivo imaging and has provided remarkable results. Howerver this technique presents several limitations, especially due to tissue autofluorescence under external illumination and weak tissue penetration of low wavelength excitation light. We have developed an alternative optical imaging technique using persistent luminescent nanoparticles suitable for small animal imaging. These nanoparticles can be excited before the injection, and their in vivo distribution can be followed in real-time for several hours. Chemical modifications of their surface is possible leading to lung or liver targeting, or to long-lasting blood circulation.

Citation Download Citation

Quentin le Masne de Chermont, Cyrille Richard, Johanne Seguin, Corinne Chanéac, Michel Bessodes, and Daniel Scherman "Silicates doped with luminescent ions: useful tools for optical imaging applications", Proc. SPIE 7189, Colloidal Quantum Dots for Biomedical Applications IV, 71890B (3 March 2009); https://doi.org/10.1117/12.819316

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