3 March 2009 Scintillating-nanoparticle-induced enhancement of absorbed radiation dose
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Abstract
Cerium-doped lanthanum fluoride colloidal nanocrystals offer a way to improve external radiation therapy through the enhanced absorption of high energy photons, as well as through the emission of UV light in the presence of radiation, providing a second cell killing mechanism. Lanthanum fluoride nanocrystals doped with 10% cerium were anhydrously synthesized in methanol as platelets 10-12 nm in diameter and 4-6 nm thick. The nanocrystals were characterized by transmission electron microscopy, energy dispersive spectroscopy (EDS), and by steady state UV-visible optical absorption and photoluminescence spectroscopy. Using an incoming gamma flux from a 137Cs source and a Fricke dosimeter solution to measure absorbed energy, a 55% enhancement of absorbed dose was measured for a 1.2 mg/ml loading of nanocrystals over exposure range from one to four kiloroentgens.
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Nathan J. Withers, Nathan J. Withers, John B. Plumley, John B. Plumley, Nicole D. Triño, Nicole D. Triño, Krishnaprasad Sankar, Krishnaprasad Sankar, Brian A. Akins, Brian A. Akins, Antonio C. Rivera, Antonio C. Rivera, Gennady A. Smolyakov, Gennady A. Smolyakov, Graham S. Timmins, Graham S. Timmins, Marek Osinski, Marek Osinski, } "Scintillating-nanoparticle-induced enhancement of absorbed radiation dose", Proc. SPIE 7189, Colloidal Quantum Dots for Biomedical Applications IV, 718917 (3 March 2009); doi: 10.1117/12.816628; https://doi.org/10.1117/12.816628
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