Design and development of multifunctional contrast agents for photoacoustic imaging

Kimberly Homan; Sobeyda Gomez; Heidi Gensler; Jignesh Shah; L. Brannon-Peppas; Stanislav Emelianov

doi:10.1117/12.807522

20 February 2009 Design and development of multifunctional contrast agents for photoacoustic imaging

Kimberly Homan, Sobeyda Gomez, Heidi Gensler, Jignesh Shah, L. Brannon-Peppas, Stanislav Emelianov

Proceedings Volume 7190, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications; 71900I (2009) https://doi.org/10.1117/12.807522
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

We have developed a multifunctional nanoagent, termed the combined imaging and therapy nanocage system (CIT-NS). This nanosystem platform consists of a poly(lactic-co-glycolic) acid polymer core and outer silver cage network. The inner core of CIT-NS is capable of carrying drugs, such as the chemotherapeutic agent doxorubicin, or imaging contrast agents, such as dyes or fluorescent compounds. The outer silver cage is specifically designed to enhance contrast in photoacoustic imaging, i.e., acoustic imaging of optical absorption. In this paper, methods to create the CIT-NS are described. Initial characterization indicates that the developed CIT-NS will significantly increase contrast in photoacoustic imaging while retaining the potential to deliver large payloads of drug simultaneously. Therefore, the CITNS may enable multi-modal imaging approaches or simultaneous imaging and therapy strategies to improve treatment and detection of cancer and other pathologies.

Citation Download Citation

Kimberly Homan, Sobeyda Gomez, Heidi Gensler, Jignesh Shah, L. Brannon-Peppas, and Stanislav Emelianov "Design and development of multifunctional contrast agents for photoacoustic imaging", Proc. SPIE 7190, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications, 71900I (20 February 2009); https://doi.org/10.1117/12.807522

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