20 February 2009 Characterization of quenched fluorescent triple helical peptides for MMP-2 and MMP-9 optical imaging
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Abstract
The prevalence of the gelatinases, MMP-2 and MMP-9, in many human tumors, including breast, colorectal, prostate and gastric cancer, make them an attractive target for molecular imaging. A self assembling homotrimeric triple helical peptide (THP), incorporating sequences from type V collagen with high specificity to MMP-2 and MMP-9, was previously developed. To investigate the viability of a THP for gelatinase imaging, we conjugated 5FAM to ..-amino groups of lysine flanking the hydrolysis site and subjected this substrate (THP-5FAM) to vitro analysis. The synthesis and in vitro results was presented.
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Philip P. Cheney, Philip P. Cheney, Gregg B. Fields, Gregg B. Fields, Samuel Achilefu, Samuel Achilefu, W. Barry Edwards, W. Barry Edwards, } "Characterization of quenched fluorescent triple helical peptides for MMP-2 and MMP-9 optical imaging", Proc. SPIE 7190, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications, 719011 (20 February 2009); doi: 10.1117/12.810096; https://doi.org/10.1117/12.810096
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