25 February 2009 Three-dimensional photonic devices fabricated by ultrafast lasers for optical sensing in lab-on-a-chip
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We report on the use of femtosecond laser pulses to fabricate photonic devices (waveguides and interferometers) inside commercial CE chips without affecting the manufacturing procedure of the microfluidic part of the device. The fabrication of single waveguides intersecting the channels allows one to perform absorption or Laser Induced Fluorescence (LIF) sensing of the molecules separated inside the microchannels. Microfluidic channels, with access holes, are fabricated using femtosecond laser irradiation followed by chemical etching. Mach-Zehnder interferometers are used for label-free sensing of the samples flowing in the microfluidic channels by means of refractive index changes detection.
© (2009) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
R. Martínez Vázquez, R. Osellame, A. Crespi, C. Dongre, H. J. W. M. Hoekstra, M. Pollnau, H. H. van den Vlekkert, R. van Weeghel, P. Watts, R. Ramponi, G. Cerullo, "Three-dimensional photonic devices fabricated by ultrafast lasers for optical sensing in lab-on-a-chip", Proc. SPIE 7203, Commercial and Biomedical Applications of Ultrafast Lasers IX, 720313 (25 February 2009); doi: 10.1117/12.809142; https://doi.org/10.1117/12.809142


Refractive index


Lab on a chip

Femtosecond phenomena



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