DPN writing on non-flat gold surfaces and detection by SERS

Robert J. Stokes; Jennifer A. Dougan; Eleanore Irvine; Jenifer Ohayon; Sergey Rozhok; Tom Levesque; Bruce Dudzik; Mike Nelson; Duncan Graham

doi:10.1117/12.811523

18 February 2009 DPN writing on non-flat gold surfaces and detection by SERS

Robert J. Stokes, Jennifer A. Dougan, Eleanore Irvine, Jenifer Ohayon, Sergey Rozhok, Tom Levesque, Bruce Dudzik, Mike Nelson, Duncan Graham

Author Affiliations +

Proceedings Volume 7207, Microfluidics, BioMEMS, and Medical Microsystems VII; 720703 (2009) https://doi.org/10.1117/12.811523
Event: SPIE MOEMS-MEMS: Micro- and Nanofabrication, 2009, San Jose, California, United States

Abstract

There is a need for fast, reliable and sensitive biosensor arrays. We have used nanostructured plasmonic gold surfaces for the detection of biological species by surface enhanced resonance Raman scattering (SERRS). Careful, directed placement by Dip-Pen Nanolithography (DPN) of the biological species or capture chemistry, within the array facilitates efficient read out via fast Raman line mapping. In addition, we can apply parallel deposition methods to enhance the throughput of these combined techniques. SERRS is an extremely sensitive spectroscopic technique that offers several advantages over conventional fluorescence detection. For example, the high sensitivity of the method allows detection of DNA capture from single plasmonic array "pixels" ~1 μm² in area. Additionally, the information rich nature of the SERRS spectrum allows multiple levels of detection to be embedded into each pixel, further increasing the information depth of the array. By moving from micro- to nano-scale features, sensor chips can contain up to 105 times more information, dramatically increasing the capacity for disease screening.

Citation Download Citation

Robert J. Stokes, Jennifer A. Dougan, Eleanore Irvine, Jenifer Ohayon, Sergey Rozhok, Tom Levesque, Bruce Dudzik, Mike Nelson, and Duncan Graham "DPN writing on non-flat gold surfaces and detection by SERS", Proc. SPIE 7207, Microfluidics, BioMEMS, and Medical Microsystems VII, 720703 (18 February 2009); https://doi.org/10.1117/12.811523

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
7 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Scanning probe lithography

Gold

Raman spectroscopy

Surface enhanced Raman spectroscopy

Plasmonics

Resonance enhancement

Raman scattering

Show All Keywords

Keywords/Phrases

Search In:

Publication Years