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13 March 2009 Iterative finite-element-based inversion for quantified detection of molecular targets using optoacoustic tomography
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Proceedings Volume 7258, Medical Imaging 2009: Physics of Medical Imaging; 725812 (2009) https://doi.org/10.1117/12.811014
Event: SPIE Medical Imaging, 2009, Lake Buena Vista (Orlando Area), Florida, United States
Abstract
We describe an improved optoacoustic tomography method, that utilizes a diffusion-based photon propagation model in order to obtain quantified reconstruction of targets embedded deep in heterogeneous scattering and absorbing tissue. For the correction we utilize an iterative finite-element solution of the light diffusion equation to build a photon propagation model. We demonstrate image improvements achieved by this method by using tissue-mimicking phantom measurements. The particular strength of the method is its ability to achieve quantified reconstructions in non-uniform illumination configurations resembling whole-body small animal imaging scenarios.
© (2009) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Thomas Jetzfellner, Daniel Razansky, Amir Rosenthal, Ralf Schulz, K.-H. Englmeier, and Vasilis Ntziachristos "Iterative finite-element-based inversion for quantified detection of molecular targets using optoacoustic tomography", Proc. SPIE 7258, Medical Imaging 2009: Physics of Medical Imaging, 725812 (13 March 2009); https://doi.org/10.1117/12.811014
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