In addition to causing loss of contrast and blurring in an image, scatter also makes quantitative measurements of xray
attenuation impossible. Many devices, methods, and models have been developed to eliminate, estimate, and correct
for the effects of scatter. Although these techniques can reduce the impact of scatter in a large-area image, no methods
have proven to be practical and sufficient to enable quantitative analysis of image data in a routine clinical setting.
This paper describes a method of scatter correction which uses moderate x-ray collimation in combination with a
correction algorithm operating on data obtained from large-area flat panel detector images. The method involves
acquiring slot collimated images of the object, and utilizing information from outside of the collimated region, in
addition to a priori data, to estimate the scatter within the collimated region. This method requires no increase dose to
the patient while providing high image quality and accurate estimates of the primary x-ray data. This scatter correction
technique was validated through beam stop experiments and comparison of theoretically calculated and measured
contrast of thin aluminum and polymethylmethacrelate objects. Measurements taken with various background material
thicknesses, both with and without a grid, showed that the slot-scatter corrected contrast and the theoretical contrast were
not significantly different given a 99% confidence interval. However, the uncorrected contrast was found to be
significantly different from the corrected and theoretical contrasts. These findings indicate that this method of scatter
correction can eliminate the effect of scatter on contrast and potentially enable quantitative x-ray imaging.