Development of a high-speed CT imaging system using EMCCD camera

Samta C. Thacker; Kai Yang; Nathan Packard; Valeriy Gaysinskiy; George Burkett; Stuart Miller; John M. Boone; Vivek Nagarkar

doi:10.1117/12.813712

13 March 2009 Development of a high-speed CT imaging system using EMCCD camera

Samta C. Thacker, Kai Yang, Nathan Packard, Valeriy Gaysinskiy, George Burkett, Stuart Miller, John M. Boone, Vivek Nagarkar

Author Affiliations +

Proceedings Volume 7258, Medical Imaging 2009: Physics of Medical Imaging; 725846 (2009) https://doi.org/10.1117/12.813712
Event: SPIE Medical Imaging, 2009, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

The limitations of current CCD-based microCT X-ray imaging systems arise from two important factors. First, readout speeds are curtailed in order to minimize system read noise, which increases significantly with increasing readout rates. Second, the afterglow associated with commercial scintillator films can introduce image lag, leading to substantial artifacts in reconstructed images, especially when the detector is operated at several hundred frames/second (fps). For high speed imaging systems, high-speed readout electronics and fast scintillator films are required. This paper presents an approach to developing a high-speed CT detector based on a novel, back-thinned electron-multiplying CCD (EMCCD) coupled to various bright, high resolution, low afterglow films. The EMCCD camera, when operated in its binned mode, is capable of acquiring data at up to 300 fps with reduced imaging area. CsI:Tl,Eu and ZnSe:Te films, recently fabricated at RMD, apart from being bright, showed very good afterglow properties, favorable for high-speed imaging. Since ZnSe:Te films were brighter than CsI:Tl,Eu films, for preliminary experiments a ZnSe:Te film was coupled to an EMCCD camera at UC Davis Medical Center. A high-throughput tungsten anode X-ray generator was used, as the X-ray fluence from a mini- or micro-focus source would be insufficient to achieve high-speed imaging. A euthanized mouse held in a glass tube was rotated 360 degrees in less than 3 seconds, while radiographic images were recorded at various readout rates (up to 300 fps); images were reconstructed using a conventional Feldkamp cone-beam reconstruction algorithm. We have found that this system allows volumetric CT imaging of small animals in approximately two seconds at ~110 to 190 μm resolution, compared to several minutes at 160 μm resolution needed for the best current systems.

Citation Download Citation

Samta C. Thacker, Kai Yang, Nathan Packard, Valeriy Gaysinskiy, George Burkett, Stuart Miller, John M. Boone, and Vivek Nagarkar "Development of a high-speed CT imaging system using EMCCD camera", Proc. SPIE 7258, Medical Imaging 2009: Physics of Medical Imaging, 725846 (13 March 2009); https://doi.org/10.1117/12.813712

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