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27 February 2009Identification of asymmetric pulmonary nodule growth using a moment-based algorithm
The growth rate of pulmonary nodules has been shown to be an indicator of malignancy, and previous work on pulmonary nodule characterization has suggested that the asymmetry of a nodule's shape may be correlated with malignancy. We have also observed that measurements in the axial direction on CT scans are less repeatable than measurements in-plane and this should be considered when making lesion size-change measurements. To address this, we present a method to measure the asymmetry of a pulmonary nodule's growth by the use of second-order central moments that are insensitive to z-direction variation. The difference in the moment ratios on each scan is used as a measure of the asymmetry of growth. To establish what level of difference is significant, the 95% confidence interval of the differences was determined on a zero-change dataset of 22 solid pulmonary nodules with repeat scans in the same session. This method was applied to a set of 47 solid, stable pulmonary nodules and a set of 49 solid, malignant nodules. The confidence interval established from the zero-change dataset was (-0.45, 0.38); nodules with differences outside this confidence interval are considered to have asymmetric growth. Of the 47 stable nodules, 12.8% (6/47) were found to have asymmetric growth compared to 24.5% (12/49) of malignant nodules. These preliminary results suggest that nodules with asymmetric growth can be identified.
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Artit C. Jirapatnakul, Anthony P. Reeves, Alberto M. Biancardi, David F. Yankelevitz, Claudia I. Henschke, "Identification of asymmetric pulmonary nodule growth using a moment-based algorithm," Proc. SPIE 7260, Medical Imaging 2009: Computer-Aided Diagnosis, 72602W (27 February 2009); https://doi.org/10.1117/12.813600