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13 March 2009 Brain tumor resection guided by fluorescence imaging and MRI image guidance
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Recent evidence suggests a correlation between extent of tumor resection and patient prognosis, making maximal tumor resection a clinical ideal for neurosurgeons. Our group is currently undertaking a clinical study using fluorescence-based detection of tumor coupled with a standard 3-D image guidance system to study the effectiveness of fluorescence-based detection in the neurosurgical operating room. For fluorescence-based detection, we used 5-aminolevulinic acid to induce accumulation of protoporphyrin IX in malignant tissues. In this paper, we chose one prototypical, highly fluorescent case of glioblastoma multiforme, a high-grade glioma, to highlight some of the key findings and methodology used in our study of fluorescence-based detection and resection of brain tumors.
© (2009) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Pablo Valdes, Brent T. Harris, Frederic Leblond, Kathryn M. Fontaine, Songbai Ji, Brian W. Pogue, Alex Hartov, David W. Roberts, and Keith D. Paulsen "Brain tumor resection guided by fluorescence imaging and MRI image guidance", Proc. SPIE 7261, Medical Imaging 2009: Visualization, Image-Guided Procedures, and Modeling, 726103 (13 March 2009);

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