27 February 2009 Choline molecular imaging with small-animal PET for monitoring tumor cellular response to photodynamic therapy of cancer
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Abstract
We are developing and evaluating choline molecular imaging with positron emission tomography (PET) for monitoring tumor response to photodynamic therapy (PDT) in animal models. Human prostate cancer (PC-3) was studied in athymic nude mice. A second-generation photosensitizer Pc 4 was used for PDT in tumor-bearing mice. MicroPET images with 11C-choline were acquired before PDT and 48 h after PDT. Time-activity curves of 11C-choline uptake were analyzed before and after PDT. For treated tumors, normalized choline uptake decreased significantly 48 h after PDT, compared to the same tumors pre-PDT (p ⪅ 0.001). However, for the control tumors, normalized choline uptake increased significantly (p ⪅ 0.001). PET imaging with 11C-choline is sensitive to detect early tumor response to PDT in the animal model of human prostate cancer.
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Baowei Fei, Baowei Fei, Hesheng Wang, Hesheng Wang, Chunying Wu, Chunying Wu, Joseph Meyers, Joseph Meyers, Liang-Yan Xue, Liang-Yan Xue, Gregory MacLennan, Gregory MacLennan, Mark Schluchter, Mark Schluchter, } "Choline molecular imaging with small-animal PET for monitoring tumor cellular response to photodynamic therapy of cancer", Proc. SPIE 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging, 726211 (27 February 2009); doi: 10.1117/12.812129; https://doi.org/10.1117/12.812129
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