20 March 2009 Three-dimensional heat-induced echo-strain imaging for monitoring high-intensity acoustic ablation
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Three dimensional heat-induced echo-strain imaging is a potentially useful tool for monitoring the formation of thermal lesions during ablative therapy. Heat-induced echo-strain, known as thermal strain, is due to the changes in the speed of propagating ultrasound signals and to tissue expansion during heat deposition. This paper presents a complete system for targeting and intraoperative monitoring of thermal ablation by high intensity focused acoustic applicators. A special software interface has been developed to enable motor motion control of 3D mechanical probes and rapid acquisition of 3D-RF data (ultrasound raw data after the beam-forming unit). Ex-vivo phantom and tissue studies were performed in a controlled laboratory environment. While B-mode ultrasound does not clearly identify the development of either necrotic lesions or the deposited thermal dose, the proposed 3D echo-strain imaging can visualize these changes, demonstrating agreement with temperature sensor readings and gross-pathology. Current results also demonstrate feasibility for realtime computation through a parallelized implementation for the algorithm used. Typically, 125 frames per volume can be processed in less than a second. We also demonstrate motion compensation that can account for shift within frames due to either tissue movement or positional error in the US 3D imaging probe.
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Emad M. Boctor, Nishikant Deshmukh, Maria S. Ayad, Clyde Clarke, Kris Dickie, Michael A Choti, Everette C. Burdette, "Three-dimensional heat-induced echo-strain imaging for monitoring high-intensity acoustic ablation", Proc. SPIE 7265, Medical Imaging 2009: Ultrasonic Imaging and Signal Processing, 72650R (20 March 2009); doi: 10.1117/12.811287; https://doi.org/10.1117/12.811287

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