17 November 2008 High-efficiency microarray of 3-D carbon MEMS electrodes for pathogen detection systems
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Proceedings Volume 7266, Optomechatronic Technologies 2008; 726615 (2008) https://doi.org/10.1117/12.806624
Event: International Symposium on Optomechatronic Technologies, 2008, San Diego, California, United States
Molecular diagnostic applications for pathogen detections require the ability to separate pathogens such as bacteria, viruses, etc., from a biological sample of blood or saliva. Over the past several years, conventional two-dimensional active microarrays have been used with success for the manipulation of biomolecules including DNA. However, they have a major drawback of inability to process relatively 'largevolume' samples useful in infectious disease diagnostics applications. This paper presents an active microarray of three-dimensional carbon electrodes that exploits electrokinetic forces for transport, accumulation, and hybridization of charged bio-molecules with an added advantage of large volume capability. Tall 3-dimensional carbon microelectrode posts are fabricated using C-MEMS (Carbon MEMS) technology that is emerging as a very exciting research area since carbon has fascinating physical, chemical, mechanical and electrical properties in addition to its low cost. The chip fabricated using CMEMS technology is packaged and its efficiency of separation and accumulation of charged particle established by manipulating negatively charged polycarboxylate 2 μm beads in 50 mM histidine buffer.
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Sam Kassegne, Sam Kassegne, Berhanu Wondimu, Berhanu Wondimu, Mohammad Majzoub, Mohammad Majzoub, Jiae Shin, Jiae Shin, "High-efficiency microarray of 3-D carbon MEMS electrodes for pathogen detection systems", Proc. SPIE 7266, Optomechatronic Technologies 2008, 726615 (17 November 2008); doi: 10.1117/12.806624; https://doi.org/10.1117/12.806624

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