Hydrodynamic flow focusing to study the isolated effects of the flow components

Francisco J. Tovar-Lopez; K. Khoshmanesh; M. Nasabi; K. Kalantar-zadeh; Gary Rosengarten; Arnan Mitchell

doi:10.1117/12.813946

30 December 2008 Hydrodynamic flow focusing to study the isolated effects of the flow components

Francisco J. Tovar-Lopez, K. Khoshmanesh, M. Nasabi, K. Kalantar-zadeh, Gary Rosengarten, Arnan Mitchell

Proceedings Volume 7270, Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems; 72700L (2008) https://doi.org/10.1117/12.813946
Event: SPIE Smart Materials, Nano- and Micro-Smart Systems, 2008, Melbourne, Australia

Abstract

Biological fluids such as blood, proteins and DNA solutions moving within fluidic channels can potentially be exposed to high level of shear, extension or mixed stress, either in vitro such as industrial processing of blood products or in vivo such as ocurrs in some pathological conditions. This exposure to a high level of strain can trigger some reactions. In most of the cases the nature of the flow is mixed with shear and extensional components. The ability to isolate the effects of each component is critical in order to understand the mechanisms behind the reactions and potentially prevent them. Applying hydrodynamic flow focusing, we present in this investigation the characterization of microchannels that allow study of the regions of high shear or high extension strain rate. Micro channels were fabricated in polydimethyl siloxane (PDMS) using standard soft-lithography techniques with a photolithographically patterned mold. Characterization of the regions with high shear and high extension strain rate is presented. Computational Fluid Dynamics (CFD) simulations in three dimensions have been carried out to gain more detailed local flow information, and the results have been validated experimentally. A comparison between the numerical models and experiment and is presented. The advantages of microfluidic flow focusing in the study of the effects of shear and extension strain rates for biological fluids are outlined.

Citation Download Citation

Francisco J. Tovar-Lopez, K. Khoshmanesh, M. Nasabi, K. Kalantar-zadeh, Gary Rosengarten, and Arnan Mitchell "Hydrodynamic flow focusing to study the isolated effects of the flow components", Proc. SPIE 7270, Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems, 72700L (30 December 2008); https://doi.org/10.1117/12.813946

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available