Microneedles array with biodegradable tips for transdermal drug delivery

Ciprian Iliescu; Bangtao Chen; Jiashen Wei; Francis E. H. Tay

doi:10.1117/12.810692

30 December 2008 Microneedles array with biodegradable tips for transdermal drug delivery

Ciprian Iliescu, Bangtao Chen, Jiashen Wei, Francis E. H. Tay

Proceedings Volume 7270, Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems; 72700M (2008) https://doi.org/10.1117/12.810692
Event: SPIE Smart Materials, Nano- and Micro-Smart Systems, 2008, Melbourne, Australia

Abstract

The paper presented an enhancement solution for transdermal drug delivery using microneedles array with biodegradable tips. The microneedles array was fabricated by using deep reactive ion etching (DRIE) and the biodegradable tips were made to be porous by electrochemical etching process. The porous silicon microneedle tips can greatly enhance the transdermal drug delivery in a minimum invasion, painless, and convenient manner, at the same time; they are breakable and biodegradable. Basically, the main problem of the silicon microneedles consists of broken microneedles tips during the insertion. The solution proposed is to fabricate the microneedle tip from a biodegradable material - porous silicon. The silicon microneedles are fabricated using DRIE notching effect of reflected charges on mask. The process overcomes the difficulty in the undercut control of the tips during the classical isotropic silicon etching process. When the silicon tips were formed, the porous tips were then generated using a classical electrochemical anodization process in MeCN/HF/H₂O solution. The paper presents the experimental results of in vitro release of calcein and BSA with animal skins using a microneedle array with biodegradable tips. Compared to the transdermal drug delivery without any enhancer, the microneedle array had presented significant enhancement of drug release.

Citation Download Citation

Ciprian Iliescu, Bangtao Chen, Jiashen Wei, and Francis E. H. Tay "Microneedles array with biodegradable tips for transdermal drug delivery", Proc. SPIE 7270, Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems, 72700M (30 December 2008); https://doi.org/10.1117/12.810692

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