Hand-held analyser based on microchip electrophoresis with contactless conductivity detection for measurement of chemical warfare agent degradation products

Karolina-Petkovic Duran; Yonggang Zhu; Chuanpin Chen; Anthony Swallow; Robert Stewart; Pam Hoobin; Patrick Leech; Simon Ovenden

doi:10.1117/12.810684

30 December 2008 Hand-held analyser based on microchip electrophoresis with contactless conductivity detection for measurement of chemical warfare agent degradation products

Karolina-Petkovic Duran, Yonggang Zhu, Chuanpin Chen, Anthony Swallow, Robert Stewart, Pam Hoobin, Patrick Leech, Simon Ovenden

Author Affiliations +

Proceedings Volume 7270, Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems; 72700Q (2008) https://doi.org/10.1117/12.810684
Event: SPIE Smart Materials, Nano- and Micro-Smart Systems, 2008, Melbourne, Australia

Abstract

This paper reports on the development of a hand-held device for on-site detection of organophosphonate nerve agent degradation products. This field-deployable analyzer relies on efficient microchip electrophoresis separation of alkyl methylphosphonic acids and their sensitive contactless conductivity detection. Miniaturized, low-powered design is coupled with promising analytical performance for separating the breakdown products of chemical warfare agents such as Soman, Sarin and VX . The detector has a detection limit of about 10 μg/mL and has a good linear response in the range 10-300 μg/mL concentration range. Applicability to environmental samples is demonstrated .The new hand-held analyzer offers great promise for converting conventional ion chromatography or capillary electrophoresis sophisticated systems into a portable forensic laboratory for faster, simpler and more reliable on-site screening.

Citation Download Citation

Karolina-Petkovic Duran, Yonggang Zhu, Chuanpin Chen, Anthony Swallow, Robert Stewart, Pam Hoobin, Patrick Leech, and Simon Ovenden "Hand-held analyser based on microchip electrophoresis with contactless conductivity detection for measurement of chemical warfare agent degradation products", Proc. SPIE 7270, Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems, 72700Q (30 December 2008); https://doi.org/10.1117/12.810684

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