23 February 2009 Influence of glycerol with different concentrations on skin optical clearing and morphological changes in vivo
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Abstract
Glycerol with high concentration can enhance optical clearing of skin by injecting into derma, but previous investigations also found that it may block the blood once glycerol acted on small vessels. This work aims to explore the safety of glycerol as an optical clearing agent of skin. Here, 0.05ml of 75%, 50%, 40%, 30%, 20% glycerol solutions and saline were injected into the dorsal dermas of SD rat, respectively. To compare the optical clearing effect, the diffuse reflectance spectra were monitored just immediately, 2h and 24h after the injection of solutions. In order to investigate the long term effect of glycerol on the local skin, the photos at the interest area were taken. The results showed that the high concentration solutions (40%, 50%, 75% glycerol) made local skin necroses badly which was irreversible in 2 weeks. The low concentration solutions (20% glycerol) could cause neither skin damage nor optical clearing effect. 30% glycerol could reduce the reflectance spectra of skin by 20% without injury. Therefore, 30% glycerol is an available agent for skin optical clearing through injection treatment.
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Zongzhen Mao, Zhenzhen Han, Xiang Wen, Qingming Luo, Dan Zhu, "Influence of glycerol with different concentrations on skin optical clearing and morphological changes in vivo", Proc. SPIE 7278, Photonics and Optoelectronics Meetings (POEM) 2008: Fiber Optic Communication and Sensors, 72781T (23 February 2009); doi: 10.1117/12.823310; https://doi.org/10.1117/12.823310
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