6 March 2009 Effective fitting depth of measurement of tissue-simulating phantom optical properties with optical coherence tomography
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Abstract
Measurement of tissue optical properties with optical coherence tomography (OCT) shows that scattering coefficient has an effect on the OCT signal slope. The slope is calculated by linear fitting with a certain range of OCT signal; hence, the effect of fitting range on the scattering induced change of slope is an important topic. In this paper, we study the scattering induced change of OCT signal slope versus depth in Intralipid suspensions with different concentrations based on Monte Carlo simulation. The results show that the OCT signal slope expresses a contrary change with scattering coefficient below a certain depth in high Intralipid concentrations, so there is an effective fitting depth. The effective fitting depth is approximately 600 μm for 10% Intralipid and increases with decreasing concentrations. The effective fitting depth is due to the face that multiple scattering photons of backscattered light become dominant below the depth, and it is related with the numeric aperture (NA) of the object lens.
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Shu Feng, Shu Feng, Kehong Yuan, Kehong Yuan, Datian Ye, Datian Ye, } "Effective fitting depth of measurement of tissue-simulating phantom optical properties with optical coherence tomography", Proc. SPIE 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine, 72800M (6 March 2009); doi: 10.1117/12.821678; https://doi.org/10.1117/12.821678
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