6 March 2009 Superficial microcirculation flow measurement using polarized light
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Depth discrimination of polarized light is used in investigating laser Doppler measurement of the superficial microcirculation in tissue. Using polarization Monte Carlo simulation, temporal point spread function and power spectral distribution of backscattered polarization remaining light firstly are used to prove polarized light to be valid in measuring moving blood cell perfusion and mean flow velocity. Then simulation of layered medium model demonstrate that relationships between blood flow perfusion and mean frequency shift are linear to medium flowing velocity, and the Doppler shift information in polarization remaining light mainly comes from lower layer medium up to about 14 times of mean free path (MFP) of medium investigated and can be considered that Doppler effects come only from lower layer of the medium. Simulations in three-layer tissue model show that moving blood cell perfusion and mean blood cell moving velocity calculated from polarization remaining are much more sensitive to lower layer flow velocity variation, and more irrelevant to deeper layer flow rate fluctuations, that further confirms Doppler measurement from polarization remaining light to be effective for superficial microcirculation in tissue. Factors affecting Laser Doppler measurement like medium absorption, percentage of moving particles in blood detector size are discussed.
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Jiwei Wu, Jiwei Wu, S. P. Morgan, S. P. Morgan, Yunshi Xiao, Yunshi Xiao, } "Superficial microcirculation flow measurement using polarized light", Proc. SPIE 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine, 728021 (6 March 2009); doi: 10.1117/12.820007; https://doi.org/10.1117/12.820007

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