6 March 2009 In vivo mouse brain tomography by fast dual-scanning photoacoustic imaging system based on array transducer
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Abstract
A full-view photoacoustic tomography system with dual-scanning using a linear transducer array for fast imaging of complicated blood network was developed. In this system, a 128-element linear transducer array was used to detect photoacoustic signals by combined scanning of electronic scan and mechanical scan. An improved limited-field filtered back projection algorithm with directivity factors was applied to reconstruct the distribution of the absorbed optical energy deposit. An in vivo experiment on a mouse brain was performed to evaluate the ability of this composite system. A clear view of the cerebrovascular network on the brain cortex was acquired successfully. Furthermore, the reconstruct images with different number of scanning positions were also investigated and analyzed to induce a compromised proposal between scanning time and scanning number. The experimental results demonstrate the multi-element photoacoustic imaging system has the potential to acquire the time-resolved functional information for fundamental research of small animal brain imaging.
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Sihua Yang, Sihua Yang, Da Xing, Da Xing, } "In vivo mouse brain tomography by fast dual-scanning photoacoustic imaging system based on array transducer", Proc. SPIE 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine, 72802B (6 March 2009); doi: 10.1117/12.821574; https://doi.org/10.1117/12.821574
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