6 April 2009 Design and operation of a fully implantable SMA actuated implant for correcting short bowel syndrome
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Abstract
Short Bowel Syndrome (SBS) is medical condition characterized by insufficient small intestine length, leading to improper nutrient absorption and significant mortality rates. The complications of current treatment methods have encouraged the development of a novel treatment method based on mechanotransduction, the process through which mechanical tensile loading induces longitudinal growth of intestine. Animal based studies with simple extension devices have demonstrated the potential of the treatment to grow healthy bowel, but an implantable device suitable for clinical use remains undeveloped. This paper presents the development of an instrumented fully implantable bowel extender based upon a shape memory alloy driven linear ratchet that can be controlled and monitored remotely. The overall bowel extender system is described with respect to specifications for pig experimental tests. The functionality of the mechanical and electrical subsystems of the device are detailed and experimentally validated on the bench top, in segments of living bowel tissue removed from a pig, and in cadaveric pigs. Mechanical loading characteristics and safe load limits on bowel tissue are identified. Results from these experiments establish the readiness of the device to be tested in living pigs, enabling studies to move one step closer to clinical studies.
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Brent Utter, Jonathan Luntz, Diann Brei, Daniel Teitelbaum, Manabu Okawada, Eiichi Miyasaka, "Design and operation of a fully implantable SMA actuated implant for correcting short bowel syndrome", Proc. SPIE 7288, Active and Passive Smart Structures and Integrated Systems 2009, 72881A (6 April 2009); doi: 10.1117/12.819397; https://doi.org/10.1117/12.819397
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