31 March 2009 Nanodevices for biosensing applications
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This research discusses the development of biosensors with vertically aligned nanowires, and the evaluation of their physical properties, electrochemical performance and biocompatibility. The developments include neurotransmitter (dopamine) sensors, glucose sensors for continuous monitoring, potassium ion sensors and integration of those sensors. A hemi-cylindrical nanocavity structure has been developed for dopamine sensing using redox cycling with radial diffusion within the cavities. By immobilization of enzymes in a conducting polymer matrix on vertically aligned nanowires, glucose sensing electrodes have been obtained with high sensitivity and selectivity. In addition, potassium sensing, potentially useful for monitoring changes of extracellular potassium concentration during myocardial ischemia, has been demonstrated using ion selective membranes (ISM) on nanowires. Sensor developments and measurement results are included in the presentation along with descriptions of top-down and bottom-up nano-/micro-fabrication technologies such as lithography and thin film deposition.
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Hargsoon Yoon, Hargsoon Yoon, Devesh C. Deshpande, Devesh C. Deshpande, Vasuda Ramachandran, Vasuda Ramachandran, Phillip T. Hankins, Phillip T. Hankins, Vijay K. Varadan, Vijay K. Varadan, } "Nanodevices for biosensing applications", Proc. SPIE 7291, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2009, 72910A (31 March 2009); doi: 10.1117/12.821552; https://doi.org/10.1117/12.821552

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