Preparation of lisinopril-capped gold nanoparticles for molecular imaging of angiotensin-converting enzyme

Yuan Li; Cesar Baeta; Omer Aras; Marie-Christine Daniel

doi:10.1117/12.818226

24 April 2009 Preparation of lisinopril-capped gold nanoparticles for molecular imaging of angiotensin-converting enzyme

Yuan Li, Cesar Baeta, Omer Aras, Marie-Christine Daniel

Author Affiliations +

Proceedings Volume 7313, Smart Biomedical and Physiological Sensor Technology VI; 731304 (2009) https://doi.org/10.1117/12.818226
Event: SPIE Defense, Security, and Sensing, 2009, Orlando, Florida, United States

Abstract

Overexpression of angiotensin-converting enzyme (ACE) has been associated with the pathophysiology of cardiac and pulmonary fibrosis. Moreover, the prescription of ACE inhibitors, such as lisinopril, has shown a favorable effect on patient outcome for patients with heart failure or systemic hypertension. Thus targeted imaging of the ACE would be of crucial importance for monitoring tissue ACE activity as well as the treatment efficacy in heart failure. In this respect, lisinopril-coated gold nanoparticles were prepared to provide a new type of probe for targeted molecular imaging of ACE by tuned K-edge computed tomography (CT) imaging. The preparation involved non-modified lisinopril, using its primary amine group as the anchoring function on the gold nanoparticles surface. The stable lisinopril-coated gold nanoparticles obtained were characterized by UV-vis spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM). Their zeta potential was also measured in order to assess the charge density on the modified gold nanoparticles (GNPs).

Citation Download Citation

Yuan Li, Cesar Baeta, Omer Aras, and Marie-Christine Daniel "Preparation of lisinopril-capped gold nanoparticles for molecular imaging of angiotensin-converting enzyme", Proc. SPIE 7313, Smart Biomedical and Physiological Sensor Technology VI, 731304 (24 April 2009); https://doi.org/10.1117/12.818226

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