29 April 2009 Microfluidic and nanofluidic integration of plasmonic substrates for biosensing
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Abstract
Metallic nanohole arrays support surface electromagnetic waves that enable enhanced optical transmission and may be exploited for sensing. Our group has been active in the application of enhanced optical transmission to chemical and biological sensing, and in the optofluidic integration nanohole arrays. Recent work in this area is described here. Recent work using a blocking layer to limit the exposed metal surface to the in-hole region resulted in effective sensing in a much smaller, nanoconfined volume. This result motivates the use of through nanoholes, (i.e. nanoholes as nanochannels) to directly address the sensing area. A flow-through nanohole array based sensing format is presented that leads to enhanced transport of reactants to the active area and a solution sieving action that is unique among surfacebased sensing methods. The pertinent fluid and solid mechanics aspects of the flow-through nanohole array sensing are discussed and recent flow-through sensing results are presented. The application of dielectrophoresis to influence particle transport in flow-through nanohole arrays is also discussed. Specifically, simulations indicate that equivalent dielectrophoretic forces are compatible with drag forces for flow rates in the range already defined in the context of biomarker transport and membrane strength considerations. Importantly, these results indicate that dielectrophoretic trapping is viable in these systems. The confinement of particles in the nanoholes opens opportunities for analyte concentration and surface enhanced Raman scattering in flow-through nanohole array based fluidic systems.
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David Sinton, Paul Wood, Carlos Escobedo, Fatemeh Eftekhari, Jacqueline Ferreira, Alexandre G. Brolo, Reuven Gordon, "Microfluidic and nanofluidic integration of plasmonic substrates for biosensing", Proc. SPIE 7322, Photonic Microdevices/Microstructures for Sensing, 732206 (29 April 2009); doi: 10.1117/12.818604; https://doi.org/10.1117/12.818604
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