7 May 2009 Theoretical and experimental development of label-free biosensors based on localized plasmon resonances on nanohole and nanopillar arrays
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Abstract
Development of localized surface plasmon resonance (LSPR) sensors for label-free biodetection draws considerable attention because of the potential of these sensors to provide simplified detection schemes, improved detection limits, and high-density multiplexed array configurations. In this paper, we present our recent results on the theoretical and experimental development of LSPR label-free biosensors based on nanohole and nanopillar arrays. First, we theoretically compare the analytical performance metrics of wavelength modulated SPR and LSPR platforms for biological recognition with surface-immobilized bioreceptors (e.g. antibodies and aptamers). Further, we discuss our results on the application of a focused ion beam (FIB) technique to fabricate arrays of nanoholes and nanopillars in Au films, investigate the origin and type of FIB-induced surface contamination, and demonstrate an efficient way for its elimination. Next, we evaluate the refractive index (RI) response sensitivity of FIB-fabricated arrays of nanoholes (443 - 513 nm/RIU) and nanopillars (423 nm/RIU) in Au films. Further, we demonstrate the opportunities that are available from the multivariate spectral analysis of plasmonic nanostructures for improvement of sensor system performance. Finally, we present typical simulation results of predicting RI sensitivity of plasmonic nanostructures using finite-difference time-domain technique (FDTD) and discuss the remaining challenges of simulation techniques for design of LSPR sensors.
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Radislav A. Potyrailo, Radislav A. Potyrailo, Katharine Dovidenko, Katharine Dovidenko, Laurie A. Le Tarte, Laurie A. Le Tarte, Cheryl Surman, Cheryl Surman, Andrew Pris, Andrew Pris, "Theoretical and experimental development of label-free biosensors based on localized plasmon resonances on nanohole and nanopillar arrays", Proc. SPIE 7322, Photonic Microdevices/Microstructures for Sensing, 73220M (7 May 2009); doi: 10.1117/12.818608; https://doi.org/10.1117/12.818608
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