Myosin helical pitch angle as a quantitative imaging biomarker for characterization of cardiac programming in fetal growth restriction measured by polarization second harmonic microscopy

I. Amat-Roldan; S, Psilodimitrakopoulos; E, Eixarch; I. Torre; B. Wotjas; F. Crispi; F. Figueras; D, Artigas; P. Loza-Alvarez; E, Gratacos

doi:10.1117/12.831481

1 July 2009 Myosin helical pitch angle as a quantitative imaging biomarker for characterization of cardiac programming in fetal growth restriction measured by polarization second harmonic microscopy

I. Amat-Roldan, S, Psilodimitrakopoulos, E, Eixarch, I. Torre, B. Wotjas, F. Crispi, F. Figueras, D, Artigas, P. Loza-Alvarez, E, Gratacos

Author Affiliations +

Proceedings Volume 7367, Advanced Microscopy Techniques; 73670O (2009) https://doi.org/10.1117/12.831481
Event: European Conferences on Biomedical Optics, 2009, Munich, Germany

Abstract

Fetal growth restriction (FGR) has recently shown a strong association with cardiac programming which predisposes to cardiovascular mortality in adulthood. Polarization Second Harmonic Microscopy can quantify molecular architecture changes with high sensitivity in cardiac myofibrils. In this work, we use myosin helical pitch angle as an example to quantify such alterations related to this high risk population. Importantly, this shows a potential use of the technique as an early diagnostic tool and an alternative method to understand pathophysiological processes.

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I. Amat-Roldan, S, Psilodimitrakopoulos, E, Eixarch, I. Torre, B. Wotjas, F. Crispi, F. Figueras, D, Artigas, P. Loza-Alvarez, and E, Gratacos "Myosin helical pitch angle as a quantitative imaging biomarker for characterization of cardiac programming in fetal growth restriction measured by polarization second harmonic microscopy", Proc. SPIE 7367, Advanced Microscopy Techniques, 73670O (1 July 2009); https://doi.org/10.1117/12.831481

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