7 July 2009 The implementation of an isotope-edited internal standard for quantification of lowest drug concentrations using surface enhanced Raman spectroscopy (SERS) in a lab on a chip device
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Abstract
The application of surface enhanced Raman spectroscopy in combination with a microfluidic device and an isotopeedited internal standard seems to be a promising way for a new approach for quantitative SERS measurements. An innovative lab on a chip system offers the possibility for reproducible, quantitative online SERS measurements based on the application of isotope labelled internal standards and liquid/liquid segmented flow based flow-through Raman detection. Errors caused by the used method can be compensated by using an internal standard.
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Anne März, Petra Rösch, Thomas Henkel, Jürgen Popp, "The implementation of an isotope-edited internal standard for quantification of lowest drug concentrations using surface enhanced Raman spectroscopy (SERS) in a lab on a chip device", Proc. SPIE 7368, Clinical and Biomedical Spectroscopy, 73680R (7 July 2009); doi: 10.1117/12.831619; https://doi.org/10.1117/12.831619
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