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13 July 2009 Dynamic retinal optical coherence microscopy without adaptive optics
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Abstract
Novel CMOS detector technology allows for high-speed volumetric tissue imaging with Fourier domain optical coherence tomography. Acquisition speeds of 200kHz reveal comprehensive image details due to the virtual lack of motion artifacts. We applied this system to the retina and achieved high resolution imaging with 5μm x 3μm transverse and axial resolution. Such resolution allows observing microscopic details such as photoreceptor cone mosaic, nerve fiber bundles, and the capillary bed without applying adaptive optics instrumentation. Fast image series reveal perfusion dynamics of full retinal volumes and allow for tracking of individual photoreceptors to study their dynamics. We observed that for in-vivo imaging speed is crucial for reproducible maps of microscopic tissue details.
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Rainer A. Leitgeb, Tilman Schmoll, and Christoph Kolbitsch "Dynamic retinal optical coherence microscopy without adaptive optics", Proc. SPIE 7372, Optical Coherence Tomography and Coherence Techniques IV, 737208 (13 July 2009); https://doi.org/10.1117/12.831794
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