13 July 2009 Spectroscopy in single and double layered weakly scattering phantoms using frequency domain optical coherence tomography
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Abstract
In this study, depth resolved measurements of absorption profiles in the wavelength range of 800 nm with a bandwidth of 140 nm are demonstrated using high speed spectroscopic frequency domain OCT (SOCT). With proper calibration, SOCT is able to extract absolute, depth resolved absorption profiles over the whole wavelength range at once without the need of tuning and performing measurements at single wavelengths sequentially. In addition, high acquisition speed in excess of 20 kHz allows to measure absorption dynamics with 50 μs time resolution, which might be useful for the investigation of pharmacokinetics or pharmacodynamics. SOCT of ~600 μm thick single- and multilayered, weakly scattering phantoms with varying absorption in the range of 10-60 cm-1, equivalent to blood absorption in capillaries, is presented. SOCT measurements are compared with those using a spectrometer in transmission mode. For Indocyanine Green (ICG), a dynamic absorption measurement is demonstrated.
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B. Hermann, B. Hermann, C. Meier, C. Meier, B. Hofer, B. Hofer, B. Považay, B. Považay, W. Drexler, W. Drexler, } "Spectroscopy in single and double layered weakly scattering phantoms using frequency domain optical coherence tomography", Proc. SPIE 7372, Optical Coherence Tomography and Coherence Techniques IV, 737210 (13 July 2009); doi: 10.1117/12.831845; https://doi.org/10.1117/12.831845
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