13 July 2009 Three-dimensional bone imaging: optical coherence tomography versus micro computer tomography
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Optical coherence tomography (OCT) and micro-computed tomography (μCT) were applied to a bone sample, a 3x4x4mm cube of fixed substantia spongiosa from an arthritic human hip. Three-dimensional image sets (1.0mm x 0.9mm x 1.6mm) were acquired with both imaging systems for the same volume of interest. For better navigation, the sample surface was additionally imaged with microscopy. The resulting OCT images were compared stepwise to the according μCT images, showing a high correlation regarding the visualization of individual trabeculae. System based imaging differences were also found: due to scattering, OCT is limited to an imaging depth of about 1mm, while μCT is capable of imaging the complete trabecular bone architecture. However, OCT images cells and the inner bone structures in contrast to μCT at similar nominal resolutions (5μm respectively 6.5μm).
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Christoph Kasseck, Christoph Kasseck, Marita Kratz, Marita Kratz, Antonia Torcasio, Antonia Torcasio, Nils C. Gerhardt, Nils C. Gerhardt, G. Harry van Lenthe, G. Harry van Lenthe, Thilo Gambichler, Thilo Gambichler, Klaus Hoffmann, Klaus Hoffmann, David B. Jones, David B. Jones, Martin R. Hofmann, Martin R. Hofmann, } "Three-dimensional bone imaging: optical coherence tomography versus micro computer tomography", Proc. SPIE 7372, Optical Coherence Tomography and Coherence Techniques IV, 73721B (13 July 2009); doi: 10.1117/12.831814; https://doi.org/10.1117/12.831814

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