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13 July 2009 Non-destructive detection of defects in artificial skin tissue by optical coherence tomography
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The application of optical coherence tomography OCT in tissue engineering facilities offers great potential for the automated detection of defects or inhomogeneities in tissue products. This non-invasive and non-destructive measurement technique enables the high speed generation of two dimensional cross sections of tissue with micron resolution. The integration of an OCT device into a tissue production facility allows the monitoring and quality control of tissue engineering products. By the selective exclusion of tissue products with insufficient quality features a high degree in production standard is guaranteed. In a first study, OCT tomograms of artificial skin equivalents were acquired and compared with microscopic images of associated histologies. As a result, a well-defined analogy of the obtained images is presented. The most common defect in terms of hole structures that occurs due to a procedural steps could be detected. Further characteristics like the topography, homogeneity and layer structure was analysed. Hence, OCT provides a powerful measurement technique to monitor the quality of tissue products in automated tissue engineering facilities.
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R. Schmitt, U. Marx, A. Heymer, and M. Kaufmann "Non-destructive detection of defects in artificial skin tissue by optical coherence tomography", Proc. SPIE 7372, Optical Coherence Tomography and Coherence Techniques IV, 73722F (13 July 2009);

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