Nanotechnology-based combination therapy improves treatment response in cancer models

Prakash Rai; Sung K. Chang; Zhiming Mai; Daniel Neuman; Tayyaba Hasan

doi:10.1117/12.828402

13 July 2009 Nanotechnology-based combination therapy improves treatment response in cancer models

Prakash Rai, Sung K. Chang, Zhiming Mai, Daniel Neuman, Tayyaba Hasan

Proceedings Volume 7380, Photodynamic Therapy: Back to the Future; 73800W (2009) https://doi.org/10.1117/12.828402
Event: 12th World Congress of the International Photodynamic Association, 2009, Seattle, Washington, United States

Abstract

Pancreatic cancer (PanCa) has a poor prognosis with a 5-year survival rate of only 5%. Photodynamic therapy (PDT) has shown promising results in treating PanCa. Mechanism-based combinations with PDT have enhanced treatment outcome. Agents tested with PDT include Avastin, an antibody against vascular endothelial growth factor (VEGF) which is approved for treating various cancers. Simultaneous delivery of drugs in nano-constructs could improve the treatment response of mechanism based combination therapies. Here, we investigate the effect of neutralizing VEGF using nanotechnology for the delivery of Avastin in combination with PDT. For this we used a construct called "nanocells" in which the photosensitizer was trapped inside polymer nanoparticles and these, with Avastin, were then encapsulated inside liposomes. In vitro, nanocells containing Avastin (NCA) significantly enhanced cytotoxicity in PanCa cells. NCA based PDT also significantly improved treatment response in mice that were orthotopically implanted with PanCa. Avastin delivered extracellularly in combination with PDT did not show any improvement. Here we propose a new paradigm for Avastin-based therapy by combining intracellular delivery of the antibody and PDT using nanotechnology for treating PanCa.

Citation Download Citation

Prakash Rai, Sung K. Chang, Zhiming Mai, Daniel Neuman, and Tayyaba Hasan "Nanotechnology-based combination therapy improves treatment response in cancer models", Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73800W (13 July 2009); https://doi.org/10.1117/12.828402

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