Selenium enhances the efficacy of Radachlorin-mediated photodynamic therapy in cervical cancer model

Dong Han Bae; Lan Ying Wen; Su Mi Bae; Uk Kang; Keun Hee Kim; Sang Hoon Jheon; Jeong Sang Lee; Woong Shick Ahn

doi:10.1117/12.824242

13 July 2009 Selenium enhances the efficacy of Radachlorin-mediated photodynamic therapy in cervical cancer model

Dong Han Bae, Lan Ying Wen, Su Mi Bae, Uk Kang, Keun Hee Kim, Sang Hoon Jheon, Jeong Sang Lee, Woong Shick Ahn

Proceedings Volume 7380, Photodynamic Therapy: Back to the Future; 73802T (2009) https://doi.org/10.1117/12.824242
Event: 12th World Congress of the International Photodynamic Association, 2009, Seattle, Washington, United States

Abstract

Selenium, an essential trace element possessing anti-carcinogenic properties, can induce apoptosis in cancer cells. Our goal was to investigate the enhanced anti-tumor effects of photodynamic therapy (PDT) plus selenium in TC-1 tumor cells implanted into mice. The MTT assay and tumor growth inhibition study were evaluated at various time intervals after the PDT plus a various dose of selenium. Following Radachlorin injections after 3 hr, the mice were then administrated selenium (2ug/kg b.w.) and then, tumors were treated with external light treatment (300 J/cm²). The selenium was administered daily for 20 days. PDT or selenium was found to be more compared to control groups. Moreover, the PDT combined with selenium demonstrated a significant suppression of tumor growth in vitro and in vivo. The tumor growth by the PDT combined with selenium was significantly reduced. These data suggest that selenium plus PDT can induce a significant tumor suppression response compared with PDT alone. Also, it can be an effective approach to induce anti-cancer therapy strategy.

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Dong Han Bae, Lan Ying Wen, Su Mi Bae, Uk Kang, Keun Hee Kim, Sang Hoon Jheon, Jeong Sang Lee, and Woong Shick Ahn "Selenium enhances the efficacy of Radachlorin-mediated photodynamic therapy in cervical cancer model", Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73802T (13 July 2009); https://doi.org/10.1117/12.824242

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KEYWORDS

Photodynamic therapy

Selenium

Tumors

Cancer

Cell death

Cervical cancer

In vivo imaging

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