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13 July 2009 Fractionated PDT with 5-aminolevulinic acid: effective, cost effective, and patient friendly
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Proceedings Volume 7380, Photodynamic Therapy: Back to the Future; 73806A (2009)
Event: 12th World Congress of the International Photodynamic Association, 2009, Seattle, Washington, United States
PDT with ALA and MAL is established as a relatively effective treatment for non-melanoma skin cancer and premalignancies. PDT is often repeated, because a single treatment gives poor long term results. Preclinical studies showed that ALA-PDT applying a fractionated illumination scheme with a small first light fraction and a second larger light fraction separated by a dark interval of two hours resulted in a significant increase in efficacy. Whereas the efficacy was not enhanced by fractionating MAL-PDT, indicating that ALA-PDT mechanism is not the same as MAL-PDT mechanism. The increase in efficacy using fractionated PDT was confirmed clinically. A randomized comparative clinical study comparing fractionated ALA-PDT versus non-fractionated ALA-PDT in the treatment of superficial basal cell carcinoma showed a significant higher response rate in the lesions treated with fractionated ALA-PDT after a follow-up of one year ( p<0.002, log-rank test). The five year follow-up is studied at moment. So far the complete response in the group treated with fractionated ALA-PDT seems to be only a few percentages lower compared to the one year follow-up. Besides the gain in response rate, fractionated ALA PDT is cost effective. ALA gel is less expensive than the commercially available MAL (Metvix) and moreover fractionated ALA-PDT takes one treatment day, instead of two treatment days using the Metvix treatment protocol (two MAL-PDT treatments separated by one week), both reducing direct and indirect costs and the burden to the patient.
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Hannah C de Vijlder, Tom A. Middelburg, Henriette S. de Bruijn, Dominic J. Robinson, H. A. Martino Neumann, and Ellen R. M. de Haas "Fractionated PDT with 5-aminolevulinic acid: effective, cost effective, and patient friendly", Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73806A (13 July 2009);

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