A novel method for multiple lifetime recovery in time-domain optical imaging

S. Fortier; G. Ma; M. Jean-Jacques

doi:10.1117/12.839912

4 August 2009 A novel method for multiple lifetime recovery in time-domain optical imaging

S. Fortier, G. Ma, M. Jean-Jacques

Proceedings Volume 7386, Photonics North 2009; 73860G (2009) https://doi.org/10.1117/12.839912
Event: Photonics North 2009, 2009, Quebec, Canada

Abstract

A new multiple lifetime fitting algorithm is presented which deconvolves a time-domain system Instrument Response Function (IRF) from a measured Fluorescence Time Point Spread Function (FTPSF) prior to lifetime fitting. Deconvolution is followed by filtering, using a special case of the optimal Wiener filter, where the signal-to-noise ratio (SNR) in the spectral domain is evaluated empirically, and thus tuned with respect to each specific FTPSF-IRF combination at hand. Comparisons between the proposed deconvolution scheme and the classical Iterative Convolution (IC) scheme over a set of simulated and experimental data reveal that the proposed scheme typically exhibits order-of-magnitude performance gains (accuracy and efficiency combined) over the IC scheme in realistic conditions.

Citation Download Citation

S. Fortier, G. Ma, and M. Jean-Jacques "A novel method for multiple lifetime recovery in time-domain optical imaging", Proc. SPIE 7386, Photonics North 2009, 73860G (4 August 2009); https://doi.org/10.1117/12.839912

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KEYWORDS

Convolution

Optical filters

Deconvolution

Electronic filtering

Luminescence

Computer simulations

Signal to noise ratio

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