21 August 2009 Glucose sensing using 3D array of reproducible surface enhanced Raman scattering substrates
Author Affiliations +
Proceedings Volume 7397, Biosensing II; 73970C (2009) https://doi.org/10.1117/12.827228
Event: SPIE NanoScience + Engineering, 2009, San Diego, California, United States
Abstract
Surface Enhanced Raman Scattering (SERS) technique is used as an indispensable and sensitive modality for bio-sensing due to its ability to distinguish the analyte molecules based on their distinct 'fingerprint' spectra. One of the most promising SERS substrates for biosensing was fabricated by coating noble metal film over orderly packed nanospheres. However, the major challenge in developing such a sensor is to achieve reproducible SERS substrate. Here, we report a new class of SERS substrate with ordered 3D nanostructures fabricated on silicon wafer by deep UV lithography technique followed by bi-metallic coating of silver and gold. Compared to the substrate fabricated by conventional nanosphere lithography, this approach allows better control of the nanostructures, which in turn gives uniform surface roughness for the metal film to provide adequate SERS enhancement with high reproducibility. Significance of this substrate for biomedical application was demonstrated by glucose sensing under physiologically relevant conditions. Partitioning and localization of glucose molecules within the first few nanometers of active SERS substrate was achieved by a self assembled monolayer (SAM) on the surface of substrate.
© (2009) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Dinish U. S, Chit Yaw Fu, Ajay Agarwal, Praveen Thoniyot, Malini Olivo, "Glucose sensing using 3D array of reproducible surface enhanced Raman scattering substrates", Proc. SPIE 7397, Biosensing II, 73970C (21 August 2009); doi: 10.1117/12.827228; https://doi.org/10.1117/12.827228
PROCEEDINGS
10 PAGES


SHARE
Back to Top