Topology, dynamics, and control in cortical blood flow elucidated with optical techniques

Philbert S. Tsai; Pablo Blinder; Patrick Drew; Jonathan Driscoll; Diana Jeong; John P. Kaufhold; Andy Shih; Ilya Valmianski; David Kleinfeld

doi:10.1117/12.829588

21 August 2009 Topology, dynamics, and control in cortical blood flow elucidated with optical techniques

Philbert S. Tsai, Pablo Blinder, Patrick Drew, Jonathan Driscoll, Diana Jeong, John P. Kaufhold, Andy Shih, Ilya Valmianski, David Kleinfeld

Author Affiliations +

Proceedings Volume 7397, Biosensing II; 739718 (2009) https://doi.org/10.1117/12.829588
Event: SPIE NanoScience + Engineering, 2009, San Diego, California, United States

Abstract

Blood is a limited resource that supplies neurons and glia with nutriments. How is blood distributed both in a fail-safe way and in response to changing metabolic loads? We examine this issue in rodent cortex. First, in terms of topology, all-optical histology is used to reconstruct the vasculature network. Second, in terms of dynamics, the flux of blood cells in individual vessels is measured in response to neuronal activation and/or the perturbation of flow of a targeted vessel via plasma-mediated ablation. Lastly, in terms of control, optical indicators of neurovascular signaling molecules that alter vessel diameter are measured.

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Philbert S. Tsai, Pablo Blinder, Patrick Drew, Jonathan Driscoll, Diana Jeong, John P. Kaufhold, Andy Shih, Ilya Valmianski, and David Kleinfeld "Topology, dynamics, and control in cortical blood flow elucidated with optical techniques", Proc. SPIE 7397, Biosensing II, 739718 (21 August 2009); https://doi.org/10.1117/12.829588

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KEYWORDS

Blood

Blood circulation

Tissues

In vivo imaging

Brain

Laser ablation

Laser scanners

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