21 August 2009 Topology, dynamics, and control in cortical blood flow elucidated with optical techniques
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Proceedings Volume 7397, Biosensing II; 739718 (2009) https://doi.org/10.1117/12.829588
Event: SPIE NanoScience + Engineering, 2009, San Diego, California, United States
Abstract
Blood is a limited resource that supplies neurons and glia with nutriments. How is blood distributed both in a fail-safe way and in response to changing metabolic loads? We examine this issue in rodent cortex. First, in terms of topology, all-optical histology is used to reconstruct the vasculature network. Second, in terms of dynamics, the flux of blood cells in individual vessels is measured in response to neuronal activation and/or the perturbation of flow of a targeted vessel via plasma-mediated ablation. Lastly, in terms of control, optical indicators of neurovascular signaling molecules that alter vessel diameter are measured.
© (2009) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Philbert S. Tsai, Philbert S. Tsai, Pablo Blinder, Pablo Blinder, Patrick Drew, Patrick Drew, Jonathan Driscoll, Jonathan Driscoll, Diana Jeong, Diana Jeong, John P. Kaufhold, John P. Kaufhold, Andy Shih, Andy Shih, Ilya Valmianski, Ilya Valmianski, David Kleinfeld, David Kleinfeld, } "Topology, dynamics, and control in cortical blood flow elucidated with optical techniques", Proc. SPIE 7397, Biosensing II, 739718 (21 August 2009); doi: 10.1117/12.829588; https://doi.org/10.1117/12.829588
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