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20 August 2009 Biomaterials based on DNA embedded in silica matrix
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Ordered DNA - silica materials have been efficiently synthesized by using the microemulsion sol - gel procedure. Dynamic Light Scattering (DLS) spectra showed that the microemulsion systems applied for DNA - silica materials synthesis contain structural units similar in size and shape. The atomic force microscopy (AFM) analysis revealed that the obtained DNA - silica thin films exhibit an ordered units array pattern structure in micron scale and the structural units channels run parallel with each. The UV - VIS reflectance spectra performed for DNA/Rhodamine - silica materials proved that the structure and properties of native DNA are protected by incorporation. The obtained results assumed a globular shape of the DNA imposed by microemulsion template and the chromophore location into its double helix structure. An improvement of the thermal properties of DNA, incorporated into the DNA - silica material, was observed by the thermogravimetric-differential thermal analysis (TGA-DTA).
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Maria Mihaly, Alina Comanescu, Adina Rogozea, Cristian Pirvu, and Ileana Rau "Biomaterials based on DNA embedded in silica matrix", Proc. SPIE 7403, Nanobiosystems: Processing, Characterization, and Applications II, 740308 (20 August 2009);

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