NASA's James Webb Space Telescope (JWST) is a 6.6m diameter, segmented, deployable telescope for cryogenic IR
space astronomy (~40K). The JWST Observatory architecture includes the Optical Telescope Element (OTE) and the
Integrated Science Instrument Module (ISIM) element that contains four science instruments (SI) including a Guider.
The SIs and Guider are mounted to a composite metering structure with outer dimensions of ~2.2x2.2x1.7m. The SI and
Guider units are integrated to the ISIM structure and optically tested at NASA Goddard Space Flight Center as an
instrument suite using a telescope simulator (Optical telescope element SIMulator; OSIM). OSIM is a high-fidelity,
cryogenic JWST telescope simulator that features a ~1.5m diameter powered mirror. The SIs are aligned to the
structure's coordinate system under ambient, clean room conditions using optomechanical metrology. OSIM is aligned
to the ISIM mechanical coordinate system at the cryogenic operating temperature via internal mechanisms and feedback
from alignment sensors in six degrees of freedom. SI performance, including focus, pupil shear, pupil roll, boresight,
wavefront error, and image quality, is evaluated at the operating temperature using OSIM. This work updates the
assembly and ambient and cryogenic optical alignment, test and verification plan for ISIM.